The corneal epithelium covers the outer part of the cornea, and its integrity is the basis of normal corneal function.
Trauma, infection, and physical abrasion can cause persistent epithelial defects, which is a major cause of vision loss in various ocular surface diseases. While treatment and prevention of corneal diseases have made significant progress, wound healing after severe corneal disease or injury remains a challenge.
In recent years, MSCs have been shown to aid in corneal surface healing as studies evaluated the effect of MSC-derived sEVs on corneal wound healing and showed that human MSC-derived sEVs significantly increased human corneal epithelial cell proliferation in vitro, and accelerated corneal wound closure. In murine epithelial mechanical injury.
Recently, MSCs have also been reported as a potential source of therapeutic cells for corneal endothelial diseases
However, MSCs exerted therapeutic effects on endothelial cell defect9 mainly through direct differentiation, and no application of MSC-derived EVs has been reported to date.
Previous studies showed that MSC were effective in prolonging corneal graft survival and exerting therapeutic effect against corneal graft rejection.
In recent years, MSCs have been shown to aid in corneal surface healing as studies evaluated the effect of MSC-derived sEVs on corneal wound healing and showed that human MSC-derived sEVs significantly increased human corneal epithelial cell proliferation in vitro, and accelerated corneal wound closure. In murine epithelial mechanical injury.
Recently, MSCs have also been reported as a potential source of therapeutic cells for corneal endothelial diseases
However, MSCs exerted therapeutic effects on endothelial cell defect9 mainly through direct differentiation, and no application of MSC-derived EVs has been reported to date.
Previous studies showed that MSC were effective in prolonging corneal graft survival and exerting therapeutic effect against corneal graft rejection.
