The corneal epithelium covers the outer portion of the cornea, and its integrity is the basis for normal corneal function.
Trauma, infection, and physical abrasion can cause persistent epithelial defects, which are a major cause of vision loss in various ocular surface diseases. While significant progress has been made in the treatment and prevention of corneal diseases, wound healing following severe corneal disease or injury remains a challenge.
In recent years, MSCs have been shown to aid in corneal surface healing. Studies have evaluated the effect of MSC-derived sEVs on corneal wound healing and demonstrated that human MSC-derived sEVs significantly increased human corneal epithelial cell proliferation in vitro, and accelerated corneal wound closure in a mechanical epithelial injury in mice.
Recently, MSCs have also been reported as a potential source of therapeutic cells for corneal endothelial diseases.
However, MSCs exerted therapeutic effects on endothelial cell defect9 mainly through direct differentiation, and no application of MSC-derived EVs has been reported so far.
Previous studies have shown that MSCs were effective in prolonging corneal graft survival and exerting therapeutic effect against corneal graft rejection.
In recent years, MSCs have been shown to aid in corneal surface healing. Studies have evaluated the effect of MSC-derived sEVs on corneal wound healing and demonstrated that human MSC-derived sEVs significantly increased human corneal epithelial cell proliferation in vitro, and accelerated corneal wound closure in a mechanical epithelial injury in mice.
Recently, MSCs have also been reported as a potential source of therapeutic cells for corneal endothelial diseases.
However, MSCs exerted therapeutic effects on endothelial cell defect9 mainly through direct differentiation, and no application of MSC-derived EVs has been reported so far.
Previous studies have shown that MSCs were effective in prolonging corneal graft survival and exerting therapeutic effect against corneal graft rejection.
